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[18F]-JNJ-64511070 is a radiopharmaceutical diagnostic agent developed as a positron emission tomography (PET) ligand for imaging in the brain. It is designed to quantify and visualize the transmembrane AMPA receptor regulatory protein gamma 8 (TARP-γ8), which is associated with synaptic density and function. The tracer binds specifically to TARP-γ8, enabling assessment of its distribution in healthy individuals and potentially in neurodegenerative diseases such as Alzheimer's disease and other dementias. The compound was developed by Janssen Pharmaceutica, with clinical studies conducted primarily for diagnostic purposes using PET imaging[2][4][5].
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