Drug intelligence / Profile preview

[18F]-JNJ-64511070

Development stage
Unknown
Lead developer
Janssen Research & Development
Modality
Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

[18F]-JNJ-64511070 is a radiopharmaceutical diagnostic agent developed as a positron emission tomography (PET) ligand for imaging in the brain. It is designed to quantify and visualize the transmembrane AMPA receptor regulatory protein gamma 8 (TARP-γ8), which is associated with synaptic density and function. The tracer binds specifically to TARP-γ8, enabling assessment of its distribution in healthy individuals and potentially in neurodegenerative diseases such as Alzheimer's disease and other dementias. The compound was developed by Janssen Pharmaceutica, with clinical studies conducted primarily for diagnostic purposes using PET imaging[2][4][5].

Other names
18F JNJ 64511070[18F] JNJ 64511070[18F]-JNJ-64511070
02

Targets

CACNG8 (Transmembrane AMPA receptor regulatory protein gamma-8)

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